03 / RESEARCH AREAS

Measuring aging

Biological clocks, biomarkers and what it means to measure change.

QUESTIONS WE WANT TO UNDERSTAND

What does a biological age estimate actually measure?
Does a change in a marker predict a meaningful health outcome?
How reproducible is a measurement across people and settings?

These questions describe the scope of this area. They are not findings or a list of active studies.

Research in this area

When an Aging Clock Turns Back, What Has Actually Changed?

A lower clock reading can be a biological signal worth investigating. Interpreting it as a younger body, less disease or a longer life requires further evidence. We reanalyzed published CALERIE blood methylation clock values, built a mixture model from sorted cells from six donors, and simulated measurement noise and multiple testing to examine those steps.

Measuring aging

What does a biological age estimate actually measure?

Does a change in a marker predict a meaningful health outcome?

How reproducible is a measurement across people and settings?

Research in this area

When an Aging Clock Turns Back, What Has Actually Changed?