RESEARCH AREAS
Start with a better question.
Seven ways into the science of aging. Explore the questions that define each area.
Mechanisms of aging
The biology beneath the passing years. From cellular change to the whole organism.
Lifestyle & function
Movement, nutrition, sleep and the capacities that make a life well lived.
Measuring aging
Biological clocks, biomarkers and what it means to measure change.
Drug research
From promising pathways to human trials, with benefits and risks in view.
The next frontiers
Regeneration, reprogramming and emerging ideas at the edge of what we know.
Population & lifespan
Patterns across lives, generations and places. Making sense of longevity at scale.
Methods & evidence
The tools of careful inquiry. Study design, causal reasoning and uncertainty.
All research
Newest published first
1–12 of 45 articles
Does a Younger “Vascular Age” Mean Improved Vascular Structure?
Vascular readings can carry health information, but a lower predicted age, a changed arterial wall, and fewer future clinical events are separate results. We reanalyzed a public dataset of 36,223…
- Cross-sectional age and algorithmsModerate
- Pressure and mechanical conditionsStrong
- Acute human tone and vessel sitesLimited
- Clinical prognosisModerate
- Management trial and surrogacyNot yet determinable
Does daily regularity have independent value, or reflect activity and health?
Regularity can describe behavior beyond movement volume, but measurement, prognosis and intervention value are separate questions. In our NHANES reanalysis, RA retains a favorable mortality…
- Measurement and finite identificationStrong
- Conditional mortality associationsModerate
- External prognostic evidenceModerate
- Short interventions and physiologyLimited
- Healthspan and clinical prescriptionsNot yet determinable
At the same weight loss, does losing visceral fat offer greater benefits?
Weight alone does not describe fat distribution or metabolic change. Randomized lifestyle trials support different visceral fat reductions with different intervention bundles, even when average…
- Randomized lifestyle bundles and fat distributionModerate
- Long-term metabolic and diabetes associationsLimited
- Fatty-acid/inflammatory pathways and selective removalLimited
- Causal extra benefit at fixed weight lossNot yet determinable
- Healthspan and routine imaging decisionsNot yet determinable
How Much Can Enhanced DNA Repair Explain Longevity Differences Between Species?
Bowhead-whale cell experiments give genome maintenance experimental support as one explanation of exceptional longevity. Several repair reporters, survival after damage and mutation outcomes favor…
- Selected cross-species cell maintenanceModerate
- Conditional locus error spectraLimited
- CIRBP cellular perturbationModerate
- Female fly survival and whole-organism tradeoffsLimited
- Whale lifespan attribution and human benefitNot yet determinable
Protein accumulation in the aging brain: made locally or acquired from other cells?
Mouse experiments support the presence of neuron-derived protein material in microglia, with higher associated labeling signals in aged microglial samples. Some labeled proteins also disappear more…
- Mouse cellular origin and recipient materialModerate
- Effective persistence in selected brain regionsModerate
- Routes, intrinsic rates and functional attributionLimited
- Normal-human aging and intervention benefitNot yet determinable
Do two longevity drugs add their benefits, or act synergistically?
A 2025 mouse experiment supports longer survival with rapamycin plus trametinib than with either drug alone under the tested strain, doses and schedule. Exceeding a single treatment, exceeding a…
- Joint survival benefit in the specified mouse regimenLimited
- Lifespan interaction and mechanistic attributionNot yet determinable
- Mouse function and molecular changesLimited
- Combined benefit in normally aging humansNot supported
How much of lifespan is heritable—and why do estimates differ so much?
There is no universal percentage of an individual's lifespan that is “decided by genes.” Heritability describes variation within a specified population, environment and measurement scale. Estimates…
- Genetic differences in lifespanModerate
- Conditional estimates in historical pedigreesLimited
- Intrinsic lifespan under zero external mortalityLimited
- An individual’s modifiable lifespan or healthspan fractionNot supported
Does Shingles Vaccination Reduce Dementia Risk?
The evidence supports a signal worth testing seriously: eligibility for live shingles vaccination is associated with fewer recorded dementia diagnoses, and birth-date discontinuities make this…
- Live-vaccine eligibility policyModerate
- Receipt and relative efficacyLimited
- Recombinant vaccination in humansLimited
- Disease-mortality signalLimited
- Mechanism, onset and lifespanNot yet determinable
If plasma exchange helps, is the effect from removal or replacement?
Changing the blood environment can change selected ageing-related phenotypes. The central experiments reviewed here do not uniquely attribute these changes to removing old factors, or establish how…
- Specified mouse combination and tissue outcomesModerate
- Removal/addition and feedback attributionLimited
- Human blood-proxy changesLimited
- Disease-specific clinical function/cognitionLimited
- Ordinary human healthspan and long-term safetyNot yet determinable
Can young microbiota transfer age-related traits back towards youth?
Some functions change with donor material; that does not establish transfer of a youthful state. Mouse studies support selected behavioral, inflammatory and barrier changes. A 2026 study identifies…
- Specified mouse material and behaviorLimited
- Specified mouse immune–neural pathwayModerate
- Broad healthspan and longevityNot yet determinable
- Ordinary human ageing interventionNot yet determinable
Matrix fragments: drivers of aging, or echoes of tissue injury?
Elastin fragments can participate in immune signaling, and mouse interventions provide causal clues. Higher circulating concentrations can also reflect tissue injury, increased release or slower…
- Circulating levels and originsLimited
- Animal signaling mechanismsModerate
- Naturally aged lifespanLimited
- Specificity and safetyLimited
- Human causality and healthspanNot yet determinable
Hepatic immune signals: new T cells, or expansion of existing cells?
A mouse study temporarily supplied three immune-support signals from the liver and improved some vaccine and antitumor responses in aged animals. Evidence for thymic involvement matters, but larger…
- Thymus-related processesModerate
- Repertoire depth and originsLimited
- Animal function and withdrawalModerate
- Model safetyLimited
- Human protection and healthspanNot yet determinable