RESEARCH AREAS

Start with a better question.

Seven ways into the science of aging. Explore the questions that define each area.

Mechanisms of aging

The biology beneath the passing years. From cellular change to the whole organism.

Explore this area

Lifestyle & function

Movement, nutrition, sleep and the capacities that make a life well lived.

Explore this area

Measuring aging

Biological clocks, biomarkers and what it means to measure change.

Explore this area

Drug research

From promising pathways to human trials, with benefits and risks in view.

Explore this area

The next frontiers

Regeneration, reprogramming and emerging ideas at the edge of what we know.

Explore this area

Population & lifespan

Patterns across lives, generations and places. Making sense of longevity at scale.

Explore this area

Methods & evidence

The tools of careful inquiry. Study design, causal reasoning and uncertainty.

Explore this area

Research in this area

1 published articles

Measuring aging

When an Aging Clock Turns Back, What Has Actually Changed?

A lower clock reading can be a biological signal worth investigating. Interpreting it as a younger body, less disease or a longer life requires further evidence. We reanalyzed published CALERIE blood methylation clock values, built a mixture model from sorted cells from six donors, and simulated measurement noise and multiple testing to examine those steps.