01 / RESEARCH AREAS

Mechanisms of aging

The biology beneath the passing years. From cellular change to the whole organism.

QUESTIONS WE WANT TO UNDERSTAND

Which changes drive aging, and which accompany it?
How do processes at different biological scales interact?
When does a mechanism found in a model apply to humans?

These questions describe the scope of this area. They are not findings or a list of active studies.

Research in this area

When an Aging Clock Turns Back, What Has Actually Changed?

A lower clock reading can be a biological signal worth investigating. Interpreting it as a younger body, less disease or a longer life requires further evidence. We reanalyzed published CALERIE blood methylation clock values, built a mixture model from sorted cells from six donors, and simulated measurement noise and multiple testing to examine those steps.

Mechanisms of aging

Which changes drive aging, and which accompany it?

How do processes at different biological scales interact?

When does a mechanism found in a model apply to humans?

Research in this area

When an Aging Clock Turns Back, What Has Actually Changed?