02 / RESEARCH AREAS
Lifestyle & function
Movement, nutrition, sleep and the capacities that make a life well lived.
QUESTIONS WE WANT TO UNDERSTAND
Which outcomes matter for daily function and healthspan?
How do baseline health and context change the evidence?
What separates a lasting effect from a short-term response?
These questions describe the scope of this area. They are not findings or a list of active studies.
Research in this area
Newest published first
1–7 of 7 articles
Does daily regularity have independent value, or reflect activity and health?
Regularity can describe behavior beyond movement volume, but measurement, prognosis and intervention value are separate questions. In our NHANES reanalysis, RA retains a favorable mortality…
- Measurement and finite identificationStrong
- Conditional mortality associationsModerate
- External prognostic evidenceModerate
- Short interventions and physiologyLimited
- Healthspan and clinical prescriptionsNot yet determinable
At the same weight loss, does losing visceral fat offer greater benefits?
Weight alone does not describe fat distribution or metabolic change. Randomized lifestyle trials support different visceral fat reductions with different intervention bundles, even when average…
- Randomized lifestyle bundles and fat distributionModerate
- Long-term metabolic and diabetes associationsLimited
- Fatty-acid/inflammatory pathways and selective removalLimited
- Causal extra benefit at fixed weight lossNot yet determinable
- Healthspan and routine imaging decisionsNot yet determinable
Can treating hearing loss slow cognitive decline?
ACHIEVE did not detect an overall cognitive benefit across its 977 participants over three years, but it found a signal in the prespecified ARIC recruitment subgroup. Three questions need separate…
- Overall RCT cognitionModerate
- Recruitment subgroup and risk enrichmentLimited
- Measurement and retestingLimited
- Disease and pathologyLimited
Protein Supports Muscle, Yet mTOR Inhibition Is Called Anti-Aging: Where Is the Contradiction?
Muscle synthesis after a meal, strength after months of training, and animal lifespan are different outcomes. Distinguishing them helps explain the apparent contradiction, without identifying an…
- Acute synthesisModerate
- Muscle mass over monthsModerate
- Human function and safetyLimited
- Timing and tissue mechanismsLimited
- Animal survivalModerate
- Human longevity translationNot yet determinable
Where Do Fasting's Extra Benefits Come From: Less Food, Meal Timing, or Longer Fasts?
Time-restricted eating can help some adults lose weight. Current trials cannot assign precise shares of benefit to reduced intake, meal timing, and fasting duration, or establish that these changes…
- Weight and adiposityModerate
- Timing and metabolismLimited
- Fasting durationNot yet determinable
- Safety and body compositionLimited
- Disease and lifespanNot yet determinable
Does Eating Less Extend Life?
In one study of genetically diverse female mice, median lifespan was 278 days longer under 40% caloric restriction than under unrestricted feeding. That result can be reproduced from…
- Survival under specific animal feeding regimensModerate
- Human metabolic markers and safetyModerate
- Human lifespanNot yet determinable
Does more exercise mean a longer life?
People who report leisure-time activity often live longer, but being able to exercise also reflects health. We reanalysed NHANES 2007–2014 questionnaires linked to public mortality files and compared…
- Activity and mortality associationModerate
- Physical functionModerate
- Randomized mortality evidenceNot yet determinable