01 / RESEARCH AREAS
Mechanisms of aging
The biology beneath the passing years. From cellular change to the whole organism.
Research in this area
Newest published first
25–29 of 29 articles
Partial reprogramming: what becomes younger—readouts, identity, or function?
Partial reprogramming can alter molecular readouts in cultured cells, but function, stability and human benefit require separate tests. Gill and colleagues’ 2022 maturation phase transient…
- Molecular readoutsLimited
- Cell identityLimited
- Cell functionLimited
- Stability and safetyNot yet determinable
Clearing Senescent Cells: When Could It Help or Harm?
Clearing senescent cells improves function or survival in some mouse models, but can also disrupt particular stages of tissue repair. The result depends on the cells, intervention, tissue and timing…
- Animal function and survivalModerate
- Human randomized skeletal evidenceLimited
- Attribution to tissue clearanceNot yet determinable
- Repair cost of clearanceModerate
- Human safetyLimited
Does Living Longer Mean Ageing More Slowly?
Longer life is a valuable outcome, but it does not by itself show that every organ ages more slowly. We reanalysed public ITP mouse data on function, body composition and pathology, and independently…
- Mouse survivalModerate
- Specific mouse functionLimited
- Selected pathologyLimited
- Attribution to overall ageing rateNot yet determinable
Rapamycin: the mouse lifespan effect is real. What is missing in humans?
Rapamycin extends survival in multiple cohorts of genetically heterogeneous mice, a result that deserves serious attention. Human trials have yet to connect that evidence to longer life or…
- Mouse survivalStrong
- Human functionLimited
- Human lifespan and long-term safetyNot yet determinable
When an Aging Clock Turns Back, What Has Actually Changed?
A lower clock reading can be a biological signal worth investigating. Interpreting it as a younger body, less disease or a longer life requires further evidence. We reanalyzed published CALERIE blood…
- Clock readings can moveModerate
- What a reversal meansNot yet determinable