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37–45 of 45 articles
Where Do Fasting's Extra Benefits Come From: Less Food, Meal Timing, or Longer Fasts?
Time-restricted eating can help some adults lose weight. Current trials cannot assign precise shares of benefit to reduced intake, meal timing, and fasting duration, or establish that these changes…
- Weight and adiposityModerate
- Timing and metabolismLimited
- Fasting durationNot yet determinable
- Safety and body compositionLimited
- Disease and lifespanNot yet determinable
Does Eating Less Extend Life?
In one study of genetically diverse female mice, median lifespan was 278 days longer under 40% caloric restriction than under unrestricted feeding. That result can be reproduced from…
- Survival under specific animal feeding regimensModerate
- Human metabolic markers and safetyModerate
- Human lifespanNot yet determinable
Partial reprogramming: what becomes younger—readouts, identity, or function?
Partial reprogramming can alter molecular readouts in cultured cells, but function, stability and human benefit require separate tests. Gill and colleagues’ 2022 maturation phase transient…
- Molecular readoutsLimited
- Cell identityLimited
- Cell functionLimited
- Stability and safetyNot yet determinable
Clearing Senescent Cells: When Could It Help or Harm?
Clearing senescent cells improves function or survival in some mouse models, but can also disrupt particular stages of tissue repair. The result depends on the cells, intervention, tissue and timing…
- Animal function and survivalModerate
- Human randomized skeletal evidenceLimited
- Attribution to tissue clearanceNot yet determinable
- Repair cost of clearanceModerate
- Human safetyLimited
Does Living Longer Mean Ageing More Slowly?
Longer life is a valuable outcome, but it does not by itself show that every organ ages more slowly. We reanalysed public ITP mouse data on function, body composition and pathology, and independently…
- Mouse survivalModerate
- Specific mouse functionLimited
- Selected pathologyLimited
- Attribution to overall ageing rateNot yet determinable
Rapamycin: the mouse lifespan effect is real. What is missing in humans?
Rapamycin extends survival in multiple cohorts of genetically heterogeneous mice, a result that deserves serious attention. Human trials have yet to connect that evidence to longer life or…
- Mouse survivalStrong
- Human functionLimited
- Human lifespan and long-term safetyNot yet determinable
Does more exercise mean a longer life?
People who report leisure-time activity often live longer, but being able to exercise also reflects health. We reanalysed NHANES 2007–2014 questionnaires linked to public mortality files and compared…
- Activity and mortality associationModerate
- Physical functionModerate
- Randomized mortality evidenceNot yet determinable
Does the Body Suddenly Age at 44 and 60?
The available results do not establish ages 44 and 60 as two universal turning points in aging. We checked the original code and data and repeated age permutations and participant resampling. The…
- Reproduction and conditional count behaviorModerate
- Locating biological transitions at 44/60 from this curveNot supported
When an Aging Clock Turns Back, What Has Actually Changed?
A lower clock reading can be a biological signal worth investigating. Interpreting it as a younger body, less disease or a longer life requires further evidence. We reanalyzed published CALERIE blood…
- Clock readings can moveModerate
- What a reversal meansNot yet determinable